2012: Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
This article is talking about 2012 efforts at developing a SARS coronavirus vaccine.
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
Published online 2012 Apr 20. doi: 10.1371/journal.pone.0035421
Conclusions:
These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.
Other info on current situation with COVID-19 and COVID-19 vaccines: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335060/
Interview with expert who sites the above article in the context of current concerns about COVID-19 vaccines.
Who else thinks that the information reported in the article is a bit out of date? Don’t we have absolutely different figures now? I googled several comparing sites and all of them provided different details. Best of all was COMPACOM review. Only verified information, references to trusted sources, examples, and case studies really attracted my attention.
The article is relevant. It’s referring to the SARS virus epidemic which was also a coronavirus and to a vaccine effort at the time.